Barnes Maze Procedure for Spatial Learning and Memory in Mice
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چکیده
منابع مشابه
The Effect of Pumpkin Seed Extract on the Spatial Learning and Memory of Adult Male Ratsin Barnes maze
Background & Aims: Memory and its role in learning have long been of interest to humans. Therefore, human beings have always sought ways to enhance their memory and reduce its deficit. In the present study, the effect of pumpkin seed extract on memory and learning in adult male rats were studied. Methods: The rats (weighing 180-220 g) were divided into 7 groups (n = 8); control, sham (control a...
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Introduction: Synaptic plasticity has been suggested as the primary physiological mechanism underlying memory formation. Many experimental approaches have been used to investigate whether the mechanisms underlying long-term potentiation (LTP) are activated during learning. Nevertheless, little evidence states that hippocampal-dependent learning triggers synaptic plasticity. In this study, we in...
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The Barnes maze is a spatial memory task that requires subjects to learn the position of a hole that can be used to escape the brightly lit, open surface of the maze. Two experiments assessed the relative importance of spatial (extra-maze) versus proximal visible cues in solving the maze. In Experiment 1, four groups of mice were trained either with or without a discrete visible cue marking the...
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The Multiple T-maze (MTM) and the Barnes maze (BM) are land mazes used for the evaluation of spatial memory. The observation that mice are performing differently in individual mazes made us test the hypothesis that differences in cognitive performances in the two land mazes would be accompanied by differences in hippocampal protein levels. C57BL/6J mice were tested in the BM and in the MTM, hip...
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MOTIVATION Spatial learning is one of the most widely studied cognitive domains in neuroscience. The Morris water maze and the Barnes maze are the most commonly used techniques to assess spatial learning and memory in rodents. Despite the fact that these tasks are well-validated paradigms for testing spatial learning abilities, manual categorization of performance into behavioral strategies is ...
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ژورنال
عنوان ژورنال: BIO-PROTOCOL
سال: 2018
ISSN: 2331-8325
DOI: 10.21769/bioprotoc.2744